Anastrozole
Alias: Arimidex
CAS No: 120511-73-1
MF: C17H19N5
MW: 293.37
Purity: 98%
Appearance: white powder.
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Anastrozole (INN) (marketed under the trade name Arimidex by AstraZeneca) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women.
Anastrozole is a drug used to treat breast cancer after surgery. Anastrozole is aromatase inhibitor.Anastrozole inhibits the enzyme aromatase,Anastrozole binds reversibly to the aromatase enzyme through competitive inhition .Anastrozole can be used in man and woman. Arimidex is the aromatase inhibitor of choice. Arimidex's mechanism of action — blocking conversion of aromatizable steroids to estrogen
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
Anastrozole has been tested for reducing estrogens, including estradiol, in men.Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention.
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Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs. Hormonal therapies interfere with the way hormones are made or how they work in the body. Many breast cancers rely on the hormone oestrogen to grow. This type of breast cancer is called oestrogen receptor-positive (ER positive) breast cancer.
After the menopause, oestrogen is no longer made in the ovaries. Instead, it’s made in the fatty tissues of the body. This happens when an enzyme called aromatase changes other hormones into oestrogen. Anastrozole is a drug called an aromatase inhibitor. It blocks this process and reduces the amount of oestrogen in the body.
When a man uses anabolic androgenic steroids (AAS), certain compounds will aromatize into estrogen. The main culprits that will do this are all testosterone esters, such as: cypionate, enanthate,dianabol, deca durabolin, and less so Boldenone (EQ). If estrogen isn't inhibited by using an AI (aromatase inhibitor), then high-estrogen side effects can occur. The most well-known side effect isgynecomastia or what is known commonly as 'gyno', 'bitch tits' or 'man breasts'. A man may notice a lump forming within his breast(s) - or under the nipple area; if not treated quickly, this can require serious surgery to remove. The lesser known but very serious side effects are caused by water retention, which can give a bloated or 'full' look.
Extra water weight to your body or face (commonly called “moon face for its round or full look) can ruin a nice physique by making a person look fat. Internally, carrying around extra water weight will strain the body’s lipids across the board. A person can expect a rise in blood pressure, heart strain, and loss in energy. Also, high estrogen can affect libido.
On the other hand, if you are too aggressive in inhibiting estrogen, by using compounds that are harsher than Arimidex, this can cause your estrogen to drop too low. As a result, you can expect erectile disfunction (ED), loss of energy, depression and low libido.
Product name | Anastrozole | |
Other Name | Arimidex | |
Molecular formula | C17H19N5 | |
Molecular weight | 293.37 | |
Appearance | White crystalline powder | |
Identification | IR
HPLC Reactive |
Conform with standard IR
Conform with standard HPLC Conform |
Solubility | Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile | Complies |
Total Impurity | max.0.5% | 0.16% |
Total Unspecified Impurity | max. 0.2% | 0.06% |
Individual unspecified impurlty | max. 0.1% | 0.06% |
Related compound B | max. 0.2% | 0.06% |
Related compound C | max. 0.2% | 0.05% |
Related compound D | max. 0.1% | 0.06% |
Related compound E | max. 0.1% | 0.05% |
Limit of cyclohexane | max. 0.08% | ND |
Limit of ethylacetate | max. 0.1% | 0.07% |
Melting point | 81.0~84.0°C | 82.5~83.2°C |
Water | max. 0.3% | 0.23% |
Residue on ignition | max. 0.1% | 0.08% |
Heavy Metals | max.0.001% | Complies |
Assay(HPLC) | 98.0%~102.0% | 98.9% |
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